A Case of Interstitial Pneumonitis in a Patient with Rheumatoid Arthritis Treated with Leflunomide / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 477-481, 2009.
Article
de Ko
| WPRIM
| ID: wpr-13556
Bibliothèque responsable:
WPRO
ABSTRACT
Leflunomide, a disease-modifying antirheumatic drug (DMARD) for the treatment of rheumatoid arthritis has been available in Korea since 2003. Leflunomide-associated interstitial pneumonitis has been appearing recently. A 25-year-old woman with a 12-month history of seronegative rheumatoid arthritis (RA) presented with acute respiratory insufficiency. She developed fever, dyspnea, and non-productive cough. Her medication history included methotrexate (15 mg/week. commencing 1 year prior) and leflunomide (20 mg/day, no loading dose, commencing 4 months prior). She was diagnosed with leflunomide-associated interstitial pneumonitis based on history, physical examination, laboratory and radiologic findings. She recovered quickly after leflunomide was withdrawn and steroids and cholestyramine were initiated quickly. We report a case of leflunomide-associated interstitial pneumonitis treated successfully with intravenous high-dose steroid and cholestyramine.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Examen physique
/
Polyarthrite rhumatoïde
/
Insuffisance respiratoire
/
Stéroïdes
/
Méthotrexate
/
Résine de cholestyramine
/
Pneumopathies interstitielles
/
Toux
/
Dyspnée
/
Fièvre
Limites du sujet:
Adult
/
Female
/
Humans
Pays comme sujet:
Asia
langue:
Ko
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2009
Type:
Article