Effects of low-dose niacin on dyslipidemia and serum phosphorus in patients with chronic kidney disease
Kidney Research and Clinical Practice
; : 21-26, 2013.
Article
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| WPRIM
| ID: wpr-142109
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ABSTRACT
BACKGROUND:
Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in patients with chronic kidney disease (CKD). We evaluated whether low-dose niacin supplementation can improve dyslipidemia, lower serum phosphorus levels, and be administered with a low frequency of adverse effects in patients with CKD.METHODS:
We retrospectively analyzed the clinical records of patients with CKD who had taken niacin from January 2009 to June 2011. We excluded patients with CKD stage 1 and 5. We then enrolled 31 patients with CKD who had taken niacin at a fixed dose of 500mg/day for 6 months. We also randomly selected 30 patients with CKD who had been taking statin for 9 months as a control group.RESULTS:
Among the 34 patients with CKD who were prescribed niacin, five (14%) complained of adverse effects, and three (8%) discontinued niacin. The proportion of patients in the niacin group who had been taking a statin or omega-3 fatty acids was 67.7% and 48.8%, respectively. In the niacin group, high-density lipoprotein cholesterol level was significantly increased and triglyceride level was significantly decreased at 12 and 24 weeks compared with baseline levels (P < 0.05). In the niacin group, phosphorous level (P < 0.05) was significantly decreased, and glomerular filtration rate (GFR) was significantly increased (P < 0.05) at 24 weeks compared with baseline values.CONCLUSION:
Low-dose niacin had a low frequency of adverse effects and also improved dyslipidemia, lowered serum phosphorus level, and increased GFR in patients with CKD. Further studies are needed to evaluate the long-term effects of low-dose niacin for renal progression of CKD.
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Indice:
WPRIM
Sujet Principal:
Phosphore
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Acides gras omega-3
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Cholestérol
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Études rétrospectives
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Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase
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Insuffisance rénale chronique
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Dyslipidémies
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Débit de filtration glomérulaire
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Lipoprotéines
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Acide nicotinique
Type d'étude:
Observational_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Kidney Research and Clinical Practice
Année:
2013
Type:
Article