Association of Exercise-Induced Asthma with Atopy in Adult Patients with Asthma-Like Symptoms / 대한내과학회지
Korean Journal of Medicine
; : 723-728, 2011.
Article
de Ko
| WPRIM
| ID: wpr-143837
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: Atopy is closely related to asthma and is a risk factor for the development and exacerbation of asthma. The aim of this study was to evaluate the association between exercise-induced asthma (EIA) and atopy in adult patients with asthma-like symptoms. METHODS: Forty young male patients with asthma-like symptoms were enrolled. Skin prick, methacholine bronchial provocation, and exercise provocation tests were performed. Current and ex-smokers were excluded. RESULTS: Exercise provocation tests were positive in 21 patients (52.5%). Airway hyperresponsiveness (AHR) to methacholine (85.7% vs. 42.1%, p = 0.007) and atopy (85.7% vs. 47.4, p = 0.017) was found more frequently in patients with EIA than in those without EIA. EIA was significantly associated with atopy score (16.5 +/- 3.0 vs. 6.5 +/- 2.0, p = 0.011), atopy index (2.1 +/- 0.3 vs. 1.0 +/- 0.3, p = 0.004), and positive responses to Dermatophagoides pteronyssinus (76.2% vs. 42.1%, p = 0.028) and Dermatophagoides farinae (76.2% vs. 36.8%, p = 0.012), but not with positive responses to pollen allergens. AHR to methacholine (odds ratio [OR]: 14.3, 95% confidence interval [CI]: 1.86-109.4) and atopy (OR: 16.9, 95% CI: 2.04-140.74) were significant risk factors for EIA. CONCLUSIONS: Atopy was a risk factor for EIA in young adult men, and sensitization to house dust mites was associated with EIA.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pollen
/
Asthme
/
Asthme à l'effort
/
Peau
/
Allergènes
/
Facteurs de risque
/
Chlorure de méthacholine
/
Hyperréactivité bronchique
/
Pyroglyphidae
/
Dermatophagoides farinae
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limites du sujet:
Adult
/
Humans
/
Male
langue:
Ko
Texte intégral:
Korean Journal of Medicine
Année:
2011
Type:
Article