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Role of TGF-1 and TGF-beta Type II receptor in gastric cancer / 대한내과학회지
Korean Journal of Medicine ; : 409-416, 2001.
Article de Ko | WPRIM | ID: wpr-150168
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. However, carcinoma cells, unlike normal cells, can escape from negative regulation by TGF-beta through lack of expression or mutation of TGF-beta receptor gene. In this study, we investigated the role of TGF-beta1 and TGF-beta type II receptors (TbetaR-II) in the progression of gastric cancer. METHODS: We analyzed TGF-beta1 and TbetaR-II mRNA expression semi-quantitatively, measured by comparative RT-PCR using GAPDH, in 23 patients who underwent gastric resection for gastric cancer. We analyzed the relationship between the clinicopathologic findings and the level of the TGF-beta1 and TbetaR-II mRNA expression in carcinoma tissues and in adjacent normal tissues of gastric cancer. RESULTS: (1) TGF-beta1 and TbetaR-II mRNA were expressed in all of the carcinoma tissues and adjacent normal tissues without statistical difference in the level of the expression. (2) The level of TGF-beta1 mRNA expression was higher in patients with early gastric cancer, negative lymph nodes or negative perineural invasion. There was no significant correlation between the level of TGF-beta1 mRNA expression and several parameters such as age, gender, tumor size, differentiation, Lauren's classification, and vascular invasion. (3) There was no significant correlation between the level of TbetaR-II mRNA expression and several prognostic variables described above. (4) There was significant correlation between the level of TGF-beta1 and TbetaR-II mRNA in carcinoma tissues. CONCLUSION: The above data indicates that TGF-beta1 may contribute in the early stages of gastric carcinogenesis. Further studies are required to clarify the role of TGF-beta 1 in gastric carcinogenesis.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Tumeurs de l'estomac / Nations Unies / ARN messager / Facteur de croissance transformant bêta / Classification / Récepteurs TGF-bêta / Cellules épithéliales / Facteur de croissance transformant bêta-1 / Carcinogenèse / Noeuds lymphatiques Type d'étude: Prognostic_studies Limites du sujet: Humans langue: Ko Texte intégral: Korean Journal of Medicine Année: 2001 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Tumeurs de l'estomac / Nations Unies / ARN messager / Facteur de croissance transformant bêta / Classification / Récepteurs TGF-bêta / Cellules épithéliales / Facteur de croissance transformant bêta-1 / Carcinogenèse / Noeuds lymphatiques Type d'étude: Prognostic_studies Limites du sujet: Humans langue: Ko Texte intégral: Korean Journal of Medicine Année: 2001 Type: Article