The molecular mechanism for nuclear transport and its application / 대한해부학회지
Anatomy & Cell Biology
; : 77-85, 2017.
Article
Dans En
| WPRIM
| ID: wpr-153457
Responsable en Bibliothèque :
WPRO
ABSTRACT
Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Transports
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Transduction du signal
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Expression des gènes
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Phénomènes physiologiques cellulaires
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Signaux de localisation nucléaire
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Pore nucléaire
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Transport nucléaire actif
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Cytoplasme
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Caryophérines
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Complexe protéique du pore nucléaire
langue:
En
Texte intégral:
Anatomy & Cell Biology
Année:
2017
Type:
Article