Osteonecrosis of the Femoral Head after Bone Marrow Transplantation
Journal of the Korean Radiological Society
; : 51-56, 2003.
Article
Dans Ko
| WPRIM
| ID: wpr-158093
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
To retrospectively review finding of osteonecrosis of the femoral head after bone marrow transplantation. MATERIALS ANDMETHODS:
We reviewed the clinical and MR findings of osteonecrosis of the femoral head in 23 of 1112 patients who underwent marrow transplantation during a five-year follow-up period lasting from 1996 to 2000.RESULTS:
Mean age at the time of diagnosis was 31 (range, 20-47) years, and the mean time from transplant to diagnosis was 17 months. All patients developed variable graft-versus-host disease and seventeen were treated with high-dose prednisolone and/or cysclosporin for severe acute or extensive chronic graft versus host disease. Osteonecrosis was diagnosed by magnetic resonance (MR) imaging, which allowed early detection of disease assessment of its stage. At the time of diagnosis, 15 hips were at stage I, 28 at stage II, two at stage III, and none at stage IV, according to the international ARCO classification system. Osteonecrosis of femoral diaphyses, the lower lumbar spine, or pelvic bones in the MR field was also found to have occurred in 11 patients. Initial treatment was conservative 21 hips underwent surgery [core decompression (n=10), vascularized fibular bone graft (n=5), and joint replacement (n=6)].CONCLUSION:
In patients receiving high-dose steroids for the treatment of graft-versus-host disease, MR screening might help detect osteonecrosis at an early stage.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Ostéonécrose
/
Os coxal
/
Rachis
/
Stéroïdes
/
Moelle osseuse
/
Prednisolone
/
Dépistage de masse
/
Études rétrospectives
/
Études de suivi
/
Transplantation de moelle osseuse
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Journal of the Korean Radiological Society
Année:
2003
Type:
Article