Irreversible Paraplegia Following One Time Prophylactic Intrathecal Chemotherapy in an Adult Patient with Acute Lymphoblastic Leukemia
Yonsei med. j
; Yonsei med. j;: 151-154, 2008.
Article
de En
| WPRIM
| ID: wpr-158188
Bibliothèque responsable:
WPRO
ABSTRACT
We present an adult female patient who developed irreversible paraplegia and areflexia four days post intrathecal chemotherapy with methotrexate, cytosine arabinoside and hydrocortisone. On magnetic resonance imaging (MRI) of the lumbar spine, diffuse gadolinium enhancement of the anterior spinal nerve roots (ventral roots) was detected. Methylprednisolone was intravenously administered at a daily dose of 30mg/kg for three days. Despite this treatment, flaccid weakness in the lower extremities and urinary retention persisted. Following consolidation chemotherapy, no improvement in neurologic status was noted. Six months later, a follow-up MRI revealed severe atrophy of the thoracic spinal cord.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Paraplégie
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Imagerie par résonance magnétique
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Leucémie-lymphome lymphoblastique à précurseurs B et T
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Antinéoplasiques
Limites du sujet:
Adult
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Female
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Humans
langue:
En
Texte intégral:
Yonsei med. j
Année:
2008
Type:
Article