Marked Recovery From Paraquat-Induced Lung Injury During Long-Term Follow-up
The Korean Journal of Internal Medicine
; : 95-100, 2009.
Article
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| WPRIM
| ID: wpr-166675
Responsable en Bibliothèque :
WPRO
ABSTRACT
BACKGROUND/AIMS:
Paraquat-induced lung injury has been considered a progressive and irreversible disease. The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up for longer than 6 months.METHODS:
We retrospectively examined high-resolution computed tomography and pulmonary function test of eight survivors with significant paraquat-induced lung injurys.RESULTS:
High-resolution computed tomography revealed a predominant pattern of irregularly shaped consolidation with traction bronchiectasis at 1-2 months after paraquat poisoning, a mixed pattern of irregularly shaped consolidation and ground-glass opacity at 3-12 months, and a mixed pattern of consolidation, groundglass opacity, and honeycombing at 1-2 years. At 3-12 months after paraquat ingestion, the areas of consolidation had markedly decreased and the decreased lung volume had returned to normal. At 1-2 years after paraquat poisoning, the cystic changes had disappeared. At 2-3 years after paraquat poisoning, the decrease in forced vital capacity had greatly improved to the normal range.CONCLUSIONS:
Recovery of nearly normal pulmonary structure and function may occur over several years following paraquat poisoning. Pulmonary function (both forced vital capacity and forced expiratory volume in 1 sec) evolved toward normal in the long-term survivors of paraquat poisoning with initial prominent lung injuries.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Paraquat
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Fibrose pulmonaire
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Facteurs temps
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Dilatation des bronches
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Tomodensitométrie
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Capacité vitale
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Volume expiratoire maximal par seconde
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Études rétrospectives
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Études de suivi
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Survivants
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
langue:
En
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2009
Type:
Article