Nidogen Plays a Role in the Regenerative Axon Growth of Adult Sensory Neurons Through Schwann Cells
Journal of Korean Medical Science
; : 654-659, 2009.
Article
de En
| WPRIM
| ID: wpr-170156
Bibliothèque responsable:
WPRO
ABSTRACT
We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play a role in it via regulation of Schwann cells. Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent. Continuous infusion of recombinant ectodomain of tumor endothelial marker 7, which specifically blocks nidogen function in Schwann cells, suppressed regenerative neurite growth in a sciatic nerve axotomy model. Taken together, it is likely that nidogen is required for proper regeneration of peripheral nerves after injury.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Cellules réceptrices sensorielles
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Cellules de Schwann
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Protéines recombinantes
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Glycoprotéines membranaires
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Mouvement cellulaire
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Neurites
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Rat Sprague-Dawley
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Axotomie
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Prolifération cellulaire
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Protéines membranaires
Limites du sujet:
Animals
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2009
Type:
Article