Association of p53 Protein Expression with Clinical Outcome in Advanced Supraglottic Cancer / 대한방사선종양학회지

ABSTRACT

PURPOSE: To determine the incidence and prognostic effect of p53 expression in patients with advanced supraglottic cancer. MATERIALS AND METHODS: Twenty-one cases of total 48 advanced supraglottic cancer patients who received postoperative adjuvant radiation therapy were evaluated by immunohistochemical staining employing p53 monoclonal antibody. RESULT: Three out of six stage III patients and four out of fifteen stage IV patients showed p53 expression without statistically significant difference (P=0.608). Five year survival rates are 93% in p53 negative, 86% in p53 positive patients and there was no significant difference (P=0.776). p53 expression does not show statistically significant correlation with primary tumor status (P=0.877), lymph node status (P=0.874) and age (P=0.64). CONCLUSION: There was no statistically significant correlation between traditionally known risk factors and p53 expression.