Characteristics of Duffy Blood Group Antigens and Their Global Distribution / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 13-20, 2013.
Article
de Ko
| WPRIM
| ID: wpr-173040
Bibliothèque responsable:
WPRO
ABSTRACT
The Duffy antigen was discovered in 1950, in a multiply transfused hemophiliac. Important progress has since been made in understanding the Duffy blood group system and its complexity. The Duffy blood group antigen (gp-Fy) is present primarily in erythrocytes, and also in endothelial cells of capillary and postcapillary venules, Purkinje cells of cerebellum, kidney, and pulmonary alveoli. The gp-Fy serves not only as a blood group antigen, but also as a receptor for chemokines, and as a receptor for Plasmodium vivax malaria parasites. The Duffy antigen is encoded by the DARC gene, its approved name is Duffy blood group chemokine receptor. Investigation of the DARC gene can help us in understanding the relationship of infectious disease to race or population. In addition, the allelic frequency of DARC varies according to the geographic area, which appears to reflect the history that mankind had adapted to environments and diseases, emigrating. As a result, further study of Duffy antigens can provide us with an integral and sound understanding of the human race.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Parasites
/
Plasmodium vivax
/
Alvéoles pulmonaires
/
Cellules de Purkinje
/
Veinules
/
Antigènes de groupe sanguin
/
Vaisseaux capillaires
/
Cervelet
/
Maladies transmissibles
/
Paludisme à Plasmodium vivax
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Blood Transfusion
Année:
2013
Type:
Article