Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling
Experimental & Molecular Medicine
; : e369-2017.
Article
de En
| WPRIM
| ID: wpr-174863
Bibliothèque responsable:
WPRO
ABSTRACT
In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Cellules dendritiques
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Protéine amyloïde A sérique
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Facteur de stimulation des colonies de granulocytes et de macrophages
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Interleukine-4
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Récepteur de facteur de croissance granulocyte-macrophage
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Récepteurs aux peptides formylés
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Récepteurs de type Toll
langue:
En
Texte intégral:
Experimental & Molecular Medicine
Année:
2017
Type:
Article