Effects of Antimetabolites on Proliferation of Rabbit Retinal Pigment Epithelial Cells
Journal of the Korean Ophthalmological Society
; : 602-607, 1996.
Article
Dans Ko
| WPRIM
| ID: wpr-176844
Responsable en Bibliothèque :
WPRO
ABSTRACT
Inspite of technical advances, the need for pharmacologic treatment of proliferative vitreoretinopathy was increased. In order to evaluate the antiproliferative effect of various antimetabolites to the rabbit retinal pigment epithelial cell, we treated cultured rabbit retinal pigment epithelial cell with different concentration of drugs to perform dose inhibition studies. We found that the antimetabolites inhibited the proliferation of rabbit retinal pigment epithelial cell in a dose dependent and a time dependent manner. The drug concentration required for 50% inhibition of cell growth (ID50) were found to be as follows (BCNU; 6.51 mg/L, 5-FU ; 8.94 mg/L, Daunorubicin; 0.03mg/L, Mitomycin-C; 0.26mg/L).
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Rétinal
/
Daunorubicine
/
Mitomycine
/
Vitréorétinopathie proliférante
/
Cellules épithéliales
/
Fluorouracil
/
Antimétabolites
langue:
Ko
Texte intégral:
Journal of the Korean Ophthalmological Society
Année:
1996
Type:
Article