A New Rat Model of Cisplatin-induced Neuropathic Pain
The Korean Journal of Pain
; : 236-243, 2015.
Article
Dans En
| WPRIM
| ID: wpr-180008
Responsable en Bibliothèque :
WPRO
ABSTRACT
BACKGROUND:
Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the outcomes of these models differ significantly among laboratories. Our object was to create a model of chemotherapy-induced neuropathy in rats with cancer.METHODS:
Female Sprague-Dawley rats were used. Mammary rat metastasis tumor (MRMT-1) cells were implanted subcutaneously in rats. Chemotherapy-induced peripheral neuropathy was induced by injection of cisplatin once a day for four days. The responses to mechanical and thermal stimuli were examined using von Frey filaments, acetone, and radiant heat.RESULTS:
Cisplatin (2 mg/kg/day) produced mechanical allodynia, while it did not induce cold allodynia or thermal hyperalgesia. This dose of cisplatin could work successfully against cancer. Body weight loss was not observed in cisplatin-treated rats, nor were other abnormal behaviors noted in the same rats.CONCLUSIONS:
Repeated injection of intraperitoneal cisplatin induced peripheral neuropathic pain in rats. Thus, this type of rat model has broad applicability in studies related to searching for the mechanism of cisplatin-induced mechanical allodynia and agents for the treatment of neuropathic pain.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Acétone
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Poids
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Cisplatine
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Rat Sprague-Dawley
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Neuropathies périphériques
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Modèles animaux
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Traitement médicamenteux
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Température élevée
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Hyperalgésie
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Métastase tumorale
Limites du sujet:
Animals
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Female
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Humans
langue:
En
Texte intégral:
The Korean Journal of Pain
Année:
2015
Type:
Article