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Associations among Body Mass Index, Insulin Resistance, and Pancreatic beta-Cell Function in Korean Patients with New-Onset Type 2 Diabetes
Article de En | WPRIM | ID: wpr-181915
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND/AIMS: We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes. METHODS: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. RESULTS: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMA-IR), homeostasis model assessment of beta-cell function (HOMA-beta), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-beta and inverse associations with the DI. CONCLUSIONS: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with beta-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Glycémie / Hémoglobine glyquée / Insulinorésistance / Marqueurs biologiques / Indice de masse corporelle / Modèles linéaires / Modèles logistiques / Analyse multifactorielle / Valeur prédictive des tests / Facteurs de risque Type d'étude: Etiology_studies / Prognostic_studies Limites du sujet: Female / Humans / Male Pays comme sujet: Asia langue: En Texte intégral: The Korean Journal of Internal Medicine Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Glycémie / Hémoglobine glyquée / Insulinorésistance / Marqueurs biologiques / Indice de masse corporelle / Modèles linéaires / Modèles logistiques / Analyse multifactorielle / Valeur prédictive des tests / Facteurs de risque Type d'étude: Etiology_studies / Prognostic_studies Limites du sujet: Female / Humans / Male Pays comme sujet: Asia langue: En Texte intégral: The Korean Journal of Internal Medicine Année: 2012 Type: Article