Prospective Randomized Trial for Postoperative Adjuvant Chemotherapy in Gastric Cancer Patients without Serosal Invasion: Preliminary Report
Journal of the Korean Gastric Cancer Association
; : 221-227, 2001.
Article
Dans Ko
| WPRIM
| ID: wpr-183099
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
We have carried out prospective randomized clinical trial to compare survival benefit and side effect among three postoperative adjuvant chemotherapeutic regimens in serosa-negative gastric cancer patients. MATENRIALS ANDMETHODS:
Total 317 cases were recognized as serosa negative and randomized into three groups at operating room. Out of them, 172 cases were excluded because of various reasons and 135 cases were analyzed finally; Group A 36 cases, Group B 49 cases, Group C 50 cases. Group A were treated with intravenous FP combination therapy, group B with MF combination therapy and group C with oral UFT(R) (mixture of Tegafur and Uracil) for one year. The median follow-up period was 30 months.RESULTS:
88.9% of Group A, 83.7% of Group B and 90.4% of Group C received adequate chemotherapy. The complication rates of Group A (44.4%) was significantly higher than group B (20.4%) and group C (24.0%)(P0.05).CONCLUSION:
This study might suggest that the survival benefit of postoperative adjuvant chemotherapy for gastric Pseudomonas aeruginosa, and therefore it may be a useful adjunct tool for detection of Pseudomonas aeruginosa infection in combination with other conventional techniques.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Blocs opératoires
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Pseudomonas aeruginosa
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Psychothérapie de groupe
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Séreuse
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Tumeurs de l'estomac
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Vomissement
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Taux de survie
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Études prospectives
/
Études de suivi
/
Tégafur
Type d'étude:
Clinical_trials
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Observational_studies
/
Prognostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Journal of the Korean Gastric Cancer Association
Année:
2001
Type:
Article