Successful treatment of Staphylococcus aureus associated rapid progressive glomerulonephritis and pulmonary hemorrhage with plasmapheresis / 대한내과학회지

ABSTRACT

A 45-year-old man was admitted for fever, myalgia, and generalized edema with multiple localized erythema. He had no healthy problem before these symptoms developed. Abdominal CT scan showed multiple abscess in the right buttock, left psoas, and both inguinal area. Blood and wound culture drawn during the hospitalization grew methicillin sensitive Staphylococcus aureus (MSSA). Although antibiotic therapy and incisional drainage of abscess pocket, acute renal insufficiency was progressed and massive pulmonary hemorrhage and acute respiratory failure were developed. In addition to antibiotics, plasmapheresis and steroid pulse therapy made him improved dramatically from acute renal failure and pulmonary hemorrhage. The renal biopsy showed pauci-immune crescentic glomerulonephritis (GN). This result supports that plasmapheresis and steroid therapy may be beneficial in the treatment of staphylococcal infection-associated GN as several groups reported.