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Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes
Article de En | WPRIM | ID: wpr-191386
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes. METHODS: Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis. RESULTS: The mean 10-year CHD and 10-year stroke risks were 14.92+/-11.53% and 4.03+/-3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01). CONCLUSION: The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.
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Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pression sanguine / Maladies cardiovasculaires / Artériopathies carotidiennes / Appréciation des risques / Maladie coronarienne / Accident vasculaire cérébral / Diabète de type 2 / Athérosclérose / Épaisseur intima-média carotidienne / Analyse de l'onde de pouls Type d'étude: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limites du sujet: Aged / Humans Pays comme sujet: Europa langue: En Texte intégral: Diabetes & Metabolism Journal Année: 2011 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pression sanguine / Maladies cardiovasculaires / Artériopathies carotidiennes / Appréciation des risques / Maladie coronarienne / Accident vasculaire cérébral / Diabète de type 2 / Athérosclérose / Épaisseur intima-média carotidienne / Analyse de l'onde de pouls Type d'étude: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limites du sujet: Aged / Humans Pays comme sujet: Europa langue: En Texte intégral: Diabetes & Metabolism Journal Année: 2011 Type: Article