An Open Assessment of the Efficacy and Safety of Venlafaxine (EFEXOR) in Patients with Major Depression / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 1150-1160, 2000.
Article
de Ko
| WPRIM
| ID: wpr-192155
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: A Multicenter open-label study was conducted to evaluate the clinical efficacy and safety of venlafaxine for the treatment in patients with major depression. METHOD: The study was done in patients with major depression diagnosed by DSM-IV who accepted venlafaxine medication. In cases of the patients taking other antidepressants, 6 weeks of venlafaxine medication was carried out after 14 days of drug excretion period and evaluation using HAM-D, MADRS, and CGI was done at baseline, and after 1, 2, 4, and 6 weeks. Regarding all side effects that had occurred during the period of our study such as their developed/disappeared time, severities, incidences, relationship with venlafaxine, managements and results have been putted into the records. RESULTS: A total of 141 patients were enrolled. Among 94 of them finished the 6 weeks of research and 41 of them did not make it through the research. Total HAM-D scores showed significant decrease after 1 week of venlafaxine medication and continous decrease through the study period. Total scores of MADRS also showed significant improvement after 1 week and continuous decrease through the study period. Similarly, CGI showed significant improvement between baseline, 1, 2, 4, and 6 weeks. There were no significant changes in vital sign, CBC, chemistry, and EKG. The commonly reported side effects of venlafaxine were nausea (10.6%), indigestion (9.5%), constipation (8.5%), and dizziness (8.5%). CONCLUSION: According to the results, venlafaxine was effective and safe in the treatment of patients with major depression.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Chimie
/
Incidence
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Constipation
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Diagnostic and stastistical manual of mental disorders (USA)
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Dépression
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Sensation vertigineuse
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Dyspepsie
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Électrocardiographie
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Signes vitaux
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Chlorhydrate de venlafaxine
Type d'étude:
Clinical_trials
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Incidence_studies
/
Prognostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Journal of Korean Neuropsychiatric Association
Année:
2000
Type:
Article