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Advantages of the single nucleotide polymorphism-based noninvasive prenatal test
Article de En | WPRIM | ID: wpr-195769
Bibliothèque responsable: WPRO
ABSTRACT
Down syndrome screening with cell-free DNA (cfDNA) in the maternal plasma has recently received much attention in the prenatal diagnostic field. Indeed, a large amount of evidence has already accumulated to show that screening tests with cfDNA are more sensitive and specific than conventional maternal serum and/or ultrasound screening. Globally, more than 1,000,000 of these noninvasive prenatal tests (NIPTs) have been performed to date. There are several different methods for NIPTs that are currently commercially available, including shotgun massively parallel sequencing, targeted massively parallel sequencing, and single nucleotide polymorphism (SNP)-based methods. All of these methods have their own advantages and disadvantages. In this review, I will focus specifically on the SNP-based NIPT.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Plasma sanguin / Diagnostic prénatal / ADN / Dépistage de masse / Échographie / Syndrome de Down / Polymorphisme de nucléotide simple / Séquençage nucléotidique à haut débit Type d'étude: Diagnostic_studies / Screening_studies langue: En Texte intégral: Journal of Genetic Medicine Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Plasma sanguin / Diagnostic prénatal / ADN / Dépistage de masse / Échographie / Syndrome de Down / Polymorphisme de nucléotide simple / Séquençage nucléotidique à haut débit Type d'étude: Diagnostic_studies / Screening_studies langue: En Texte intégral: Journal of Genetic Medicine Année: 2015 Type: Article