Genetic Mutation in Korean Patients of Sudden Cardiac Arrest as a Surrogating Marker of Idiopathic Ventricular Arrhythmia
Journal of Korean Medical Science
; : 1021-1026, 2013.
Article
Dans En
| WPRIM
| ID: wpr-196071
Responsable en Bibliothèque :
WPRO
ABSTRACT
Mutation or common intronic variants in cardiac ion channel genes have been suggested to be associated with sudden cardiac death caused by idiopathic ventricular tachyarrhythmia. This study aimed to find mutations in cardiac ion channel genes of Korean sudden cardiac arrest patients with structurally normal heart and to verify association between common genetic variation in cardiac ion channel and sudden cardiac arrest by idiopathic ventricular tachyarrhythmia in Koreans. Study participants were Korean survivors of sudden cardiac arrest caused by idiopathic ventricular tachycardia or fibrillation. All coding exons of the SCN5A, KCNQ1, and KCNH2 genes were analyzed by Sanger sequencing. Fifteen survivors of sudden cardiac arrest were included. Three male patients had mutations in SCN5A gene and none in KCNQ1 and KCNH2 genes. Intronic variant (rs2283222) in KCNQ1 gene showed significant association with sudden cardiac arrest (OR 4.05). Four male sudden cardiac arrest survivors had intronic variant (rs11720524) in SCN5A gene. None of female survivors of sudden cardiac arrest had SCN5A gene mutations despite similar frequencies of intronic variants between males and females in 55 normal controls. Common intronic variant in KCNQ1 gene is associated with sudden cardiac arrest caused by idiopathic ventricular tachyarrhythmia in Koreans.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Troubles du rythme cardiaque
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Variation génétique
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Fibrillation ventriculaire
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Marqueurs génétiques
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Mort subite cardiaque
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Tachycardie ventriculaire
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Prédisposition génétique à une maladie
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Canal potassique KCNQ1
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Canaux potassiques éther-à-go-go
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République de Corée
Limites du sujet:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2013
Type:
Article