Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women / 예방의학회지
Journal of Preventive Medicine and Public Health
; : 36-46, 2014.
Article
Dans En
| WPRIM
| ID: wpr-198652
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVES:
To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history.METHODS:
We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged > or =65 years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period 150 microg/d. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status.RESULTS:
Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the >150 microg/d group, compared with the 51 to 100 microg/d group, was 1.56 (95% CI, 1.03 to 2.37) in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the >150 microg/d group, compared with the 51 to 100 microg/d group, was 1.93 (95% CI, 1.14 to 3.26).CONCLUSIONS:
While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Ostéoporose
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Thyroxine
/
Facteurs temps
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Examen des demandes de remboursement d'assurance
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Modèles des risques proportionnels
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Études de cohortes
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Bases de données factuelles
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Appréciation des risques
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Fractures osseuses
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Adhésion au traitement médicamenteux
Type d'étude:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Aged
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Aged80
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Female
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Humans
langue:
En
Texte intégral:
Journal of Preventive Medicine and Public Health
Année:
2014
Type:
Article