Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model
Yonsei Medical Journal
; : 1095-1100, 2014.
Article
Dans En
| WPRIM
| ID: wpr-207153
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
The aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model. MATERIALS ANDMETHODS:
We used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma).RESULTS:
Diclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85+/-0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs.CONCLUSION:
Diclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thiazines
/
Thiazoles
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Butanones
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Piroxicam
/
Anti-inflammatoires non stéroïdiens
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Diclofenac
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Naproxène
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Rat Wistar
/
Douleur pelvienne
/
Plancher pelvien
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
Yonsei Medical Journal
Année:
2014
Type:
Article