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Mutational Analysis of Caspase-7 and 8 Genes in Non-small Cell Lung Cancer
Journal of Lung Cancer ; : 38-41, 2005.
Article de Ko | WPRIM | ID: wpr-207841
Bibliothèque responsable: WPRO
ABSTRACT
PURPOSE : Several lines of evidence have indicated that deregulation of apoptosis is involved in the mechanism of cancer development. Caspase-8 activation plays a central role in the initiation phase of apoptosis, while caspase-7 is one of the main execution phase caspases of apoptosis. The aim of this study was to explore the possibility that genetic alterations of the caspase-8 and caspase-7 genes are involved in the development of human non-small cell lung cancer (NSCLC). MATERIALS AND METHODS : We have analyzed the entire coding region of both the caspase-7 and caspase-8 genes to detect the somatic mutations in 100 NSCLCs by using polymerase chain reaction (PCR)- single strand conformation polymorphism (SSCP). RESULTS : The PCR-SSCP analysis detected no mutations in the entire coding regions of both the caspase-7 and caspase-8 genes in the NSCLCs. CONCLUSION : The data presented here suggests that both the caspase-7 and caspase-8 genes may not be somatically mutated in human NSCLCs
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Réaction de polymérisation en chaîne / Apoptose / Carcinome pulmonaire non à petites cellules / Caspases / Caspase-7 / Caspase 8 / Codage clinique Limites du sujet: Humans langue: Ko Texte intégral: Journal of Lung Cancer Année: 2005 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Réaction de polymérisation en chaîne / Apoptose / Carcinome pulmonaire non à petites cellules / Caspases / Caspase-7 / Caspase 8 / Codage clinique Limites du sujet: Humans langue: Ko Texte intégral: Journal of Lung Cancer Année: 2005 Type: Article