Blastoid Mantle Cell Lymphoma: A Case Report / 대한피부과학회지
Korean Journal of Dermatology
; : 684-688, 2010.
Article
Dans Ko
| WPRIM
| ID: wpr-210549
Responsable en Bibliothèque :
WPRO
ABSTRACT
Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually as a manifestation of disseminated disease. The immunophenotype of MCL is characterized as CD20+, CD5+ and Cyclin D1+. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. In the blastoid variant, the genetic profile is often more complex and includes tetraploid chromosomes, CCND1 amplification, a higher incidence of p53 gene mutations, and p16(INK4a) deletions. We report a case of a 62-year-old male patient who presented with erythematous subcutaneous nodules on the lower back. He had been treated for BV-MCL of the testis which had occurred 1 year ago. The analysis of histopathological and immunohistochemical examinations of the skin lesions also revealed a BV-MCL.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peau
/
Testicule
/
Lymphocytes B
/
Incidence
/
Gènes p53
/
Cyclines
/
Inhibiteur p16 de kinase cycline-dépendante
/
Lymphome à cellules du manteau
/
Tétraploïdie
/
Lymphomes
Type d'étude:
Incidence_studies
/
Prognostic_studies
Limites du sujet:
Humans
/
Male
langue:
Ko
Texte intégral:
Korean Journal of Dermatology
Année:
2010
Type:
Article