Clinical Outcome of Remnant Thyroid Ablation with Low Dose Radioiodine in Korean Patients with Low to Intermediate-risk Thyroid Cancer
Journal of Korean Medical Science
; : 876-881, 2015.
Article
de En
| WPRIM
| ID: wpr-210699
Bibliothèque responsable:
WPRO
ABSTRACT
Radioiodine activity required for remnant thyroid ablation is of great concern, to avoid unnecessary exposure to radiation and minimize adverse effects. We investigated clinical outcomes of remnant thyroid ablation with a low radioiodine activity in Korean patients with low to intermediate-risk thyroid cancer. For remnant thyroid ablation, 176 patients received radioiodine of 1.1 GBq, under a standard thyroid hormone withdrawal and a low iodine diet protocol. Serum levels of thyroid stimulating hormone stimulated thyroglobulin (off-Tg) and thyroglobulin-antibody (Tg-Ab), and a post-therapy whole body scan (RxWBS) were evaluated. Completion of remnant ablation was considered when there was no visible uptake on RxWBS and undetectable off-Tg (<1.0 ng/mL). Various factors including age, off-Tg, and histopathology were analyzed to predict ablation success rates. Of 176 patients, 68.8% (n = 121) who achieved successful remnant ablation were classified into Group A, and the remaining 55 were classified into Group B. Group A presented with significantly lower off-Tg at the first radioiodine administration (pre-ablative Tg) than those of Group B (1.2 +/- 2.3 ng/mL vs. 6.2 +/- 15.2 ng/mL, P = 0.027). Pre-ablative Tg was the only significant factor related with ablation success rates. Diagnostic performances of pre-ablative Tg < 10.0 ng/mL were sensitivity of 99.1%, specificity of 14.0%, positive predictive value of 71.1%, and negative predictive value of 87.5%, respectively. Single administration of low radioiodine activity could be sufficient for remnant thyroid ablation in patients with low to intermediate-risk thyroid cancer. Pre-ablative Tg with cutoff value of 10.0 ng/mL is a promising factor to predict successful remnant ablation.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thyroglobuline
/
Glande thyroide
/
Tumeurs de la thyroïde
/
Thyréostimuline
/
Résultat thérapeutique
/
République de Corée
/
Radio-isotopes de l'iode
Type d'étude:
Etiology_studies
/
Guideline
/
Prognostic_studies
Limites du sujet:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2015
Type:
Article