Serotonin Syndrome After an Overdose of Dextromethorphan and Chlorpeniramine: Two Case Reports
Journal of The Korean Society of Clinical Toxicology
; : 19-22, 2013.
Article
de Ko
| WPRIM
| ID: wpr-212416
Bibliothèque responsable:
WPRO
ABSTRACT
Dextromethorphan and chlorpeniramine are common ingredients of over-the-counter (OTC) cough pills. They are known to be safe when used alone, however, combination with other serotonergic drugs or use of an overdose can cause serotonergic toxicity. We report on a 43-year-old male and a 57-year-old female who ingested an overdose of antitussive drugs containing dextromethorphan and chlorpeniramine. They commonly presented with altered mentality and hyperreflexia on both upper and lower extremities. After conservative therapies, they were discharged with alert mentality. These cases are meaningful in that there are few cases of serotonin syndrome with an overdose of a combination of dextromethorphan and chlorpeniramine. Careful use with medication counseling for OTC cough pills is needed in order to prevent overdose of these ingredients.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Antitussifs
/
Sérotonine
/
Réflexes anormaux
/
Agents sérotoninergiques
/
Syndrome sérotoninergique
/
Toux
/
Assistance
/
Membre inférieur
/
Dextrométhorphane
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
langue:
Ko
Texte intégral:
Journal of The Korean Society of Clinical Toxicology
Année:
2013
Type:
Article