A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus / 대한간학회지
The Korean Journal of Hepatology
; : 381-386, 2008.
Article
Dans Ko
| WPRIM
| ID: wpr-219564
Responsable en Bibliothèque :
WPRO
ABSTRACT
Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage. This is the first report of severe hypophosphatemic osteomalacia induced by ADV at 10 mg/day. A 42-year-old man with HBV-related chronic liver disease presented with generalized bone pain, especially in the left ankle. He had been taking ADV for more than 1.5 years following a clinical breakthrough due to lamivudine-resistant HBV. Aggravating severe hypophosphatemia and elevated serum alkaline phosphatase levels with high bone fraction had been noted after 6 months of ADV therapy. Bone densitometry, simple bone X-rays, and a whole-body bone scan demonstrated osteoporosis and multiple areas with hot uptake, especially in the left ankle. All the image findings and symptoms improved after correcting the hypophosphatemia.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Antiviraux
/
Acides phosphoreux
/
ADN viral
/
Adénine
/
Tomodensitométrie
/
Absorptiométrie photonique
/
Densité osseuse
/
Virus de l'hépatite B
/
Hypophosphatémie
/
Lamivudine
Limites du sujet:
Adult
/
Humans
/
Male
langue:
Ko
Texte intégral:
The Korean Journal of Hepatology
Année:
2008
Type:
Article