Enhanced Expression of Proliferating Cell Nuclear Antigen in Psoriatic Epidermis
Annals of Dermatology
; : 169-171, 1995.
Article
de En
| WPRIM
| ID: wpr-219724
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: The proliferating cell nuclear antigen(PCNA), one of the markers for proliferating cells, has been detected in solid human neoplasms. Psoriasis is a benign hyperproliferative disorder of the skin. OBJECTIVE: This study has been made to investigate if PCNA can be detected in the psoriatic epidermis. METHODS: Specimens from 10 patients with psoriasis were stained for PCNA using the one hour immunoalkaline phosphatase technique. RESULTS: The psoriatic epidermis showed positive nuclear staining in 20%-61% (mean, 45.7%) of keratinocytes. CONCLUSION: PCNA seems to be involved in the mechanism of increased epidermal cell proliferation in psoriatic lesions.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Psoriasis
/
Peau
/
Kératinocytes
/
Antigène nucléaire de prolifération cellulaire
/
Prolifération cellulaire
/
Épiderme
Limites du sujet:
Humans
langue:
En
Texte intégral:
Annals of Dermatology
Année:
1995
Type:
Article