Systemic White Blood Cell Count as a Biomarker Associated with Severity of Chronic Obstructive Lung Disease / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 304-310, 2017.
Article
de En
| WPRIM
| ID: wpr-220957
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome. METHODS: The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses. RESULTS: The WBC count was negatively associated with forced vital capacity (FVC, L), FVC (% predicted), forced expiry volume in one second (FEV₁, L), and FEV₁ (% predicted) in COPD patients. Additionally, the WBC count was independently associated with the quality of life measure, by EQ5D-index score. However, this relationship between WBC count, and disease severity, was not significant in current smokers, because of the confounding effect of smoking, on the WBC count. CONCLUSION: The WBC count is associated with current smoking status and COPD severity, and a risk factor for poor lung function, and quality of life, especially in non-currently smoking COPD patients. The WBC count can be used, as an easily measurable COPD biomarker.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Qualité de vie
/
Tests de la fonction respiratoire
/
Fumée
/
Fumer
/
Modèles linéaires
/
Capacité vitale
/
Facteurs de risque
/
Broncho-pneumopathie chronique obstructive
/
Numération des leucocytes
/
Leucocytes
Type d'étude:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adult
/
Humans
langue:
En
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2017
Type:
Article