Relationship of Serum Adiponectin and Resistin Levels with Breast Cancer Risk
Journal of Korean Medical Science
; : 117-121, 2007.
Article
Dans En
| WPRIM
| ID: wpr-226394
Responsable en Bibliothèque :
WPRO
ABSTRACT
Obesity is one of the well-known risk factors of breast cancer. We evaluated the relationship between serum adiponectin and resistin levels and breast cancer risk in 41 biopsy-proven breast cancer patients and 43 age- and body mass index-matched controls. The mean serum adiponectin level was lower in the breast cancer group than the control group (6.93+/-3.2 microgram/mL, vs. 7.60+/-3.5 microgram/mL), but this difference did not reach statistical significance (p=0.37). There was a statistically significant difference in serum resistin levels between the groups (breast cancer group 5.23+/-6.9 ng/mL vs. control 1.46+/-2.0 ng/mL; p<0.001). The risk of breast cancer was significantly increased in the highest tertile group for serum resistin level compared to the lowest tertile group (adjusted odds ratio 2.77 [95% CI 1.40-5.50]). The lymph node metastasis was significantly increased in the patients with less than the median adiponectin level (p=0.017). In the patients whose resistin level was higher than the median, the frequency of tumor with the highest histological grade was significantly increased (p=0.025). In conclusions, both the low serum adiponectin levels and high resistin levels are likely to be associated with increased breast cancer risk in Korean women.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs du sein
/
Insulinorésistance
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Études cas-témoins
/
Odds ratio
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Adiponectine
/
Résistine
Type d'étude:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Female
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Humans
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2007
Type:
Article