Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male
Nutrition Research and Practice
; : 505-512, 2012.
Article
de En
| WPRIM
| ID: wpr-227496
Bibliothèque responsable:
WPRO
ABSTRACT
Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males' Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Qualité de vie
/
Spermatogenèse
/
Spermatozoïdes
/
Stress physiologique
/
Testostérone
/
Vieillissement
/
Taux de survie
/
Enquêtes et questionnaires
/
Stress oxydatif
/
Taraxacum
Type d'étude:
Diagnostic_studies
Limites du sujet:
Animals
/
Humans
/
Male
langue:
En
Texte intégral:
Nutrition Research and Practice
Année:
2012
Type:
Article