Bone protection effects of a novel Chinese herbal formula, taikong yangxin prescription, in hindlimb unloaded rats against bone deterioration / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 759-764, 2015.
Article
Dans En
| WPRIM
| ID: wpr-229565
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ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effects of a Chinese herbal formula, taikong yangxin prescription (TKYXP) against bone deterioration in a hindlimb unloaded (tail-suspension) rat model.</p><p><b>METHODS</b>Thirty-two male Sprague-Dawley rats were divided into 4 groups tail-suspension group fed with 2.5 g•kg(-1)•day(-1) of TKYXP extract (high dose), tail-suspension group fed with 1.25 g•kg(-1)•day(-1) (low dose), tail-suspended group treated with water placebo (placebo control group) and non tail-suspended group. The effects of TKYXP on bone were assessed using peripheral quantitative computed tomography (pQCT), microcomputerized tomography (micro-CT) and three-point bending biomechanical test on the femur in vivo.</p><p><b>RESULTS</b>TKYXP had a significant protective effect against bone loss induced by tail-suspension on day 28, as shown in the reduction in bone mineral density (BMD) loss, preservation of bone micro-architecture and biomechanical strength. The administration ofhigh dose TKYXP could significantly reduce the total BMD loss by 4.8% and 8.0% at the femur and tibia regions, respectively, compared with the placebo control group (P<0.01) on day 28. Its bone protective effect on the femur was further substantiated by the increases of the trabecular BMD (by 6.6%), bone volume fraction (by 20.9%), trabecular number (by 9.5%) and thickness (by 11.9%) as compared with the placebo control group.</p><p><b>CONCLUSION</b>TKYXP may protect the bone under weightless influence from gradual structural deterioration in the tail-suspension model.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Tibia
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Impesanteur
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Phénomènes biomécaniques
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Os et tissu osseux
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Imagerie diagnostique
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Médicaments issus de plantes chinoises
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Densité osseuse
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Tomodensitomètre
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Rat Sprague-Dawley
Type d'étude:
Diagnostic_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
Chinese journal of integrative medicine
Année:
2015
Type:
Article