KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects
Annals of the Academy of Medicine, Singapore
; : 488-492, 2011.
Article
Dans En
| WPRIM
| ID: wpr-229619
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>Type 2 diabetes (T2D) candidate gene potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects.</p><p><b>MATERIALS AND METHODS</b>The KCNQ1 single nucleotide polymorphisms (SNPs) rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects.</p><p><b>RESULTS</b>The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006).</p><p><b>CONCLUSION</b>The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Haplotypes
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Analyse de séquence d'ADN
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Polymorphisme de nucléotide simple
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Diabète de type 2
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Canal potassique KCNQ1
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Ethnologie
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Génétique
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Génétique des populations
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Malaisie
Limites du sujet:
Adult
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Female
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Humans
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Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Annals of the Academy of Medicine, Singapore
Année:
2011
Type:
Article