Role of RASSF1A hypermethylation in prostate cancer / 中华男科学杂志
National Journal of Andrology
; (12): 822-825, 2007.
Article
de Zh
| WPRIM
| ID: wpr-232054
Bibliothèque responsable:
WPRO
ABSTRACT
RASSF1A gene cloned from 3p21.3 region is a novel candidate tumor suppressor gene. The aberrant methylation of CpG lands in the promoter region is the major inactivation mechanism of RASSF1A, and is significantly involved in the genesis and development of multiple solid tumors including prostate cancer. The methylation status examination of RASSF1A could serve as an important technique for the early diagnosis of prostate cancer, while methylation inhibitor is likely to become a novel therapeutic agent.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs de la prostate
/
Méthylation de l'ADN
/
Protéines suppresseurs de tumeurs
/
Diagnostic précoce
/
Diagnostic
/
Génétique
Type d'étude:
Diagnostic_studies
/
Screening_studies
Limites du sujet:
Humans
/
Male
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2007
Type:
Article