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Lidamycin metabolism in vitro / 药学学报
Yao Xue Xue Bao ; (12): 1132-1136, 2011.
Article de Zh | WPRIM | ID: wpr-233023
Bibliothèque responsable: WPRO
ABSTRACT
This paper is to report the study of the metabolism of lidamycin in vitro including in plasma and microsomes to guide clinical therapy. Lidamycin was quantified by detecting its active ingredient using HPLC-MS/MS. The metabolic stability of lidamycin in rat, Beagle dog, monkey and human plasma and liver microsomes, and its inhibition to cytochrome P450 isoforms in human liver microsomes were studied. Results showed that lidamycin was metabolized in the four species of plasma, and the sequence of metabolic rates in plasma were in rat > in dog > in human > in monkey. But among the four species of liver microsomes, lidamycin was metabolized only in monkey liver microsomes. There was almost no inhibition to cytochrome P450 isoforms at the concentrations of between 0.0005 and 10 ng x mL(-1). Therefore, the property of lidamycin metabolism in human is similar with that in dog, and metabolism of other drugs would not be decreased by cytochrome P450 as used along with lidamycin in clinic.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Sang / Microsomes du foie / Chromatographie en phase liquide à haute performance / Cytochrome P-450 CYP1A2 / Cytochrome P-450 enzyme system / Activation enzymatique / Ènediynes / Spectrométrie de masse en tandem / Aminosides / Macaca Limites du sujet: Animals / Humans langue: Zh Texte intégral: Yao Xue Xue Bao Année: 2011 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Sang / Microsomes du foie / Chromatographie en phase liquide à haute performance / Cytochrome P-450 CYP1A2 / Cytochrome P-450 enzyme system / Activation enzymatique / Ènediynes / Spectrométrie de masse en tandem / Aminosides / Macaca Limites du sujet: Animals / Humans langue: Zh Texte intégral: Yao Xue Xue Bao Année: 2011 Type: Article