Analysis on the genetic characteristics of the wide-type measles virus circulating in Zhejiang province in 2005 / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 406-408, 2006.
Article
Dans Zh
| WPRIM
| ID: wpr-233938
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the genetic characteristics of measles viruses circulating in Zhejiang province in 2005.</p><p><b>METHODS</b>4 groups of measles viruses isolated in outbreaks and the H and N gene were amplified by reverse transcription polymerase chain reaction (RT-PCR). PCR products were purified, sequenced and data was analyzed.</p><p><b>RESULTS</b>All of the 4 measles isolates belonged to genotype H1 which had been a main genotype containing all of the isolates in China. The isolates shared 99.2% -99.7% identity of amino acid sequence on H and 99.8% identity of amino acid sequence on N gene. When comparing to the China vaccine strain (Shanghai 191), there were 95.2%-95.5% homogeneties and 95.5% homogeneties on H and N gene respectively.</p><p><b>CONCLUSION</b>Data from phylogenic trees of H and N gene revealed that the wide-type measles viruses circulating in Zhejiang province in 2005 all belonged to genotype H1. There were obvious differences on genetic characteristics between the isolates and the genotype A (Shanghai 191).</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Phylogenèse
/
Chine
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Épidémiologie
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Séquence d'acides aminés
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Classification
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Gènes viraux
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Génétique
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Génotype
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Rougeole
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Virus de la rougeole
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
Chinese Journal of Epidemiology
Année:
2006
Type:
Article