Outcomes of 104 children with B-cell non-Hodgkin lymphoma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 399-403, 2013.
Article
Dans Zh
| WPRIM
| ID: wpr-235439
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze outcomes and prognostic factors of children with B-cell non-Hodgkin lymphoma (B-NHL).</p><p><b>METHODS</b>One hundred and four newly diagnosed B-NHL children were enrolled in protocol of B-NHL 2001. The statistics were performed by SPSS 13.0.</p><p><b>RESULTS</b>Of 104 children (79 males, the median age of 7.1 years), 60, 32 and 4 patients were diagnosed with Burkitt lymphoma, diffuse large B-cell lymphoma and unclassifiable B-cell lymphoma, respectively. Four patients were in stage Ⅰ, 27 stage Ⅱ, 55 stage Ⅲ and 18 stage Ⅳ; 1, 26 and 77 patients were allocated into R1, R2 and R3 risk groups, respectively. Three patients never got complete remission (CR), 9 patients relapsed after CR with the duration of relapse from 1 to 7 months after chemotherapy. The estimated 5-year EFS of 104 patients was (86.7 ± 3.5)%. Univariable analyses identified that risk factors for recurrence were of higher staging, elevated LDH, serum ferritin and poor early response. Age, sex, pathologic diagnosis, original tumor, bone or marrow involvement, C-MYC and risk group were not found to be associated with the risk of failure to treatment. Multivariable COX regression models confirmed serum ferritin as a significant independent prognostic marker.</p><p><b>CONCLUSION</b>B-NHL 2001 protocol was reasonable for B-NHL children. Higher staging, elevated LDH, serum ferritin and poor early response increased risk for recurrence.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Lymphome malin non hodgkinien
/
Protocoles de polychimiothérapie antinéoplasique
/
Études prospectives
/
Lymphome B
/
Résultat thérapeutique
/
Utilisations thérapeutiques
/
Diagnostic
/
Traitement médicamenteux
Type d'étude:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
langue:
Zh
Texte intégral:
Chinese Journal of Hematology
Année:
2013
Type:
Article