Association of tumor necrosis factor-alpha gene polymorphisms with Henoch-Schonlein purpura nephritis in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 88-90, 2013.
Article
Dans Zh
| WPRIM
| ID: wpr-236865
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship of tumor necrosis factor-alpha (TNF-α)-308G/A gene polymorphisms with Henoch-Schonlein purpura nephritis (HSPN) in children.</p><p><b>METHODS</b>Using the direct DNA sequencing method, polymorphisms in the TNF-α promoter region (-308) were genotyped in 110 Han children with Henoch-Schonlein purpura (HSP group), including 52 children with nephritis and 58 children without nephritis. Plasma TNF-α levels were measured using ELISA. Ninety ethnically matched healthy children were used as the control group.</p><p><b>RESULTS</b>There were no significant differences in the polymorphisms of TNF-α (-308G/A) between the HSP and control groups (P>0.05). The GA genotype (29% vs 10%) and A allele frequency (18% vs 7%) in HSP children with nephritis (HSPN) were more common than in those without nephritis (P<0.05). Plasma TNF-α levels in HSPN children with GA+AA genotype (7.1±2.3 pg/mL) were significantly higher than those with GG genotype (5.7±1.5 pg/mL) (P<0.05).</p><p><b>CONCLUSIONS</b>TNF-α-308GA genotype and A allele may contribute to the increased risk for the development of nephritis in children with HSP.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polymorphisme génétique
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Facteur de nécrose tumorale alpha
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Fréquence d'allèle
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Génétique
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Génotype
Limites du sujet:
Adolescent
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Child
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2013
Type:
Article