Effect of enteral nutrition on liver function and inflammatory response after abdominal operation in patients complicated with liver dysfunction / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 336-339, 2011.
Article
Dans Zh
| WPRIM
| ID: wpr-237121
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of enteral nutrition(EN) on liver function and inflammatory response after abdominal operation in patients with liver dysfunction.</p><p><b>METHODS</b>A prospective multicenter study was conducted. Patients requiring EN for at least 5 days after abdominal surgery with at least 1 abnormal liver function index were included. After operations, EN suspensions(TPF-FOS) were administered for 5 days after the return of bowel function with targeted content of 125.52 kJ(30 kcal)·kg(-1)·d(-1) maintained for a minimum of 3 days. Levels of serum pre-albumin, C-reaction protein(CRP), and liver function index were measured and the incidence of systemic inflammatory response syndrome(SIRS) was recorded before operation and 6 days after EN. Occurrence of gastrointestinal discomfort was monitored during the treatment.</p><p><b>RESULTS</b>No statistically significant difference was found in pre-albumin between preoperative level and post-EN level[(175.94±71.79) mg/L vs.(192.22±91.26) mg/L, P=0.162]. Patients with abnormal level of γ-glutamyl transpeptidase were less after EN compared to the preoperative period(30 vs. 40, P=0.041), as was total bilirubin (3 vs. 9, P=0.034). No significant differences in other indices of liver function were found. Total bilirubin and direct bilirubin decreased after EN support(P=0.000 and P=0.015, respectively). CRP was notably reduced after EN support [(48.74±65.16) mg/L vs.(25.79±23.63) mg/L, P=0.009] and the incidence of SIRS largely declined after EN support(19.0% vs. 10.3%, P=0.059). The incidence of gastrointestinal discomfort was 22.4% on postoperative day 1 and declined to 19.0% on postoperative day 5.</p><p><b>CONCLUSION</b>For patients with liver dysfunction, enteral nutrition support with TPF-FOS after abdominal operation can reduce inflammatory response, improve liver function, and maintain serum protein level.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Complications postopératoires
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Période postopératoire
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Chirurgie générale
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Procédures de chirurgie digestive
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Thérapeutique
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Études prospectives
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Nutrition entérale
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Abdomen
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Inflammation
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Foie
Type d'étude:
Clinical_trials
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Observational_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2011
Type:
Article