Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population / 中华男科学杂志
National Journal of Andrology
; (12): 413-416, 2003.
Article
de Zh
| WPRIM
| ID: wpr-238010
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To investigate Bsm I single nucleotide polymorphism (SNP) of vitamin D receptor gene (VDRG) in low-risk Chinese Han population and its relationship to the susceptibility to prostate cancer (PCa), and to discuss the possible reason for the racial difference of PCa.</p><p><b>METHODS</b>One hundred and three patients with PCa and 106 normal controls, mainly from Northern Chinese Han population, were enrolled in this study. Their blood samples were obtained, all of which were genotyped for Bsm I SNP by denaturing high performance liquid chromatography(DHPLC) methods using case-control study.</p><p><b>RESULTS</b>The distribution of genotype and allele had no significant difference between PCa patients and normal controls (P > 0.05). The frequencies for the bb, Bb and BB genotypes in PCa patients and normal controls were 92.23%/94.34%, 7.77%/5.66%, and 0/0, respectively. The frequencies for B and b allele were 3.88%, 96.12% and 2.91%, 97.09%, respectively.</p><p><b>CONCLUSIONS</b>The results indicate no significant relationship between the VDRG polymorphisms and PCa in Northern Chinese Han population. The distribution of VDRG Bsm I SNP varies in different ethnic populations, which may be one reason for the racial difference of PCa.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs de la prostate
/
Études cas-témoins
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Chine
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Chromatographie en phase liquide à haute performance
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Récepteur calcitriol
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Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Ethnologie
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Génétique
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Génotype
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Aged
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Aged80
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Humans
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Male
Pays comme sujet:
Asia
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2003
Type:
Article