Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia / 中华男科学杂志
National Journal of Andrology
; (12): 253-256, 2012.
Article
de Zh
| WPRIM
| ID: wpr-238987
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the pregnancy promoting effect of L-carnitine combined with intracytoplasmic sperm injection (ICSI) in treating male infertility with oligoasthenozoospermia.</p><p><b>METHODS</b>We assigned 129 patients with oligoasthenozoospermia to receive 2 weeks of oral L-carnitine followed by ICSI (medication group, n = 42) and ICSI alone (control group, n = 87). We compared the sperm concentration and motility, the percentage of grade a + b sperm, and sperm deformity before and after L-carnitine medication, as well as the rates of fertilization, cleavage, available embryo and clinical pregnancy between the two groups.</p><p><b>RESULTS</b>The percentage of grade a + b sperm was significantly increased after L-carnitine medication as compared with the baseline ([13.5 +/- 10.7] % vs [9.6 +/- 7.2] %, P<0.05), and so was the rate of available embryo in the medication group after ICSI in comparison with that of the control group (77.50% vs 69.04%, P<0.05).</p><p><b>CONCLUSION</b>Short-term medication of L-carnitine can improve sperm quality and raise the success rate of ICSI.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Oligospermie
/
Thérapeutique
/
Issue de la grossesse
/
Carnitine
/
Injections intracytoplasmiques de spermatozoïdes
/
Utilisations thérapeutiques
/
Asthénozoospermie
/
Infertilité masculine
/
Méthodes
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
langue:
Zh
Texte intégral:
National Journal of Andrology
Année:
2012
Type:
Article