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Clinical applications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in carcinoma of unknown primary / 中华医学杂志(英文版)
Chin. med. j ; Chin. med. j;(24): 1010-1014, 2011.
Article de En | WPRIM | ID: wpr-239903
Bibliothèque responsable: WPRO
ABSTRACT
<p><b>BACKGROUND</b>Carcinoma of unknown primary (CUP) encompasses a heterogeneous group of tumors with varying clinical features. The management of patients of CUP remains a clinical challenge. The purpose of this study was to evaluate the clinical applications of integrated (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) information in patients with CUP, including detecting the occult primary tumor and effecting on disease therapy.</p><p><b>METHODS</b>One hundred and forty-nine patients with histologically-proven metastases of CUP were included. For all patients, the conventional diagnostic work-up was unsuccessful in localizing the primary site. Whole-body PET/CT images were obtained approximately 60 minutes after intravenous injection of 350 - 425 MBq of (18)F-FDG.</p><p><b>RESULTS</b>In 24.8% of patients, FDG PET/CT detected primary tumors that were not apparent after conventional workup. In this group of patients, the overall sensitivity, specificity, and accuracy rates of FDG PET/CT in detecting unknown primary tumors were 86.0%, 87.7%, and 87.2%, respectively. FDG PET/CT imaging also led to the detection of previously unrecognized metastases in 29.5% of patients. Forty-seven (31.5%, 47 of 149) patients underwent a change in therapeutic management.</p><p><b>CONCLUSIONS</b>FDG PET/CT is a valuable tool in patients with CUP, because it assisted in detecting unknown primary tumors and previously unrecognized distant metastases, and optimized the management of these patients.</p>
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Anatomopathologie / Imagerie diagnostique / Carcinomes / Radiographie / Reproductibilité des résultats / Fluorodésoxyglucose F18 / Tomographie par émission de positons / Méthodes Type d'étude: Diagnostic_studies Limites du sujet: Adult / Aged / Female / Humans / Male langue: En Texte intégral: Chin. med. j Année: 2011 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Anatomopathologie / Imagerie diagnostique / Carcinomes / Radiographie / Reproductibilité des résultats / Fluorodésoxyglucose F18 / Tomographie par émission de positons / Méthodes Type d'étude: Diagnostic_studies Limites du sujet: Adult / Aged / Female / Humans / Male langue: En Texte intégral: Chin. med. j Année: 2011 Type: Article