Pathological features of light chain nephropathy / 中华病理学杂志
Zhonghua Bing Li Xue Za Zhi
; (12): 506-510, 2003.
Article
de Zh
| WPRIM
| ID: wpr-242150
Bibliothèque responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the pathologic features and diagnostic algorithm of light chain nephropathy (LCN).</p><p><b>METHODS</b>Seven cases of LCN were studied by light microscopy, electron microscopy and immunolabeling of light chains (kappa, lambda) by immunofluorescence and immunoelectron microscopy.</p><p><b>RESULTS</b>The histopathology of 7 cases by light microscopy was variable, with 3 cases showing nodular glomerulosclerosis, 1 case showing mild to moderate mesangial proliferation, and 3 cases showing cast nephropathy with minimal glomerular change. Immunofluorescence study revealed positive staining of a single type of light chain in mesangium (nodular pattern) or along glomerular basement membrane (linear), along tubular basement membrane and around arteriolar walls in all the 7 cases. Ultrastructurally, electron-dense granular deposits were identified in mesangium, subendothelial aspect of glomerular basement membrane, outer aspect of tubular basement membrane and arteriolar walls. Immunogold labeling of light chains showed distinct labeling of a single type light chain in the granular electron-dense materials (5 cases being kappa-positive and 2 being lambda-positive).</p><p><b>CONCLUSIONS</b>LCN typically shows nodular glomerulosclerosis. The ultrastructural change is characteristic and important for diagnosis. Immunolabeling of light chains by immunofluorescence and immunoelectron microscopy carries further diagnostic value, especially in cases with minimal light microscopic change.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Glomérulonéphrite segmentaire et focale
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Microscopie immunoélectronique
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Chaines légères kappa des immunoglobulines
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Chaines lambda des immunoglobulines
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Chaines légères des immunoglobulines
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Allergie et immunologie
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Maladies du rein
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Glomérule rénal
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Microscopie de fluorescence
Type d'étude:
Prognostic_studies
Limites du sujet:
Adult
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Aged
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Zhonghua Bing Li Xue Za Zhi
Année:
2003
Type:
Article