A case of myelodysplastic syndrome with aberrant evolution of chromosome 1 and 11 in 6 years of follow-up / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 469-472, 2010.
Article
Dans Zh
| WPRIM
| ID: wpr-243332
Responsable en Bibliothèque :
WPRO
ABSTRACT
This study was aimed to investigate the relationship between cytogenetic evolution and disease progression in patient with MDS-RAEB. By a long term (6 years) follow-up of a patient with MDS-RAEB, peripheral blood cell count, bone marrow cell morphology and conventional cytogenetics were monitored regularly. In addition, fluorescence in situ hybridization (FISH) was applied to confirm the aberrant karyotype. The results indicated that this patient was failed with conventional chemotherapy of AML, but had response to ATRA and 6-MP in the 72 months follow-up. At initial diagnosis, the cytogenetics analysis showed normal karyotype, whereas 46, XY, 2q+[1]/46, XY[19] was found at 48 months, 46, XY, dup(1q)[3]/46, XY[7] at 56 months, and dup (1) as well as der (11) with complex karyotype at 68 months, which was accompanied by progressive decrease of platelet count. It is concluded that karyotype evolution is perhaps associated with progression of MDS.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Syndromes myélodysplasiques
/
Chromosomes humains de la paire 1
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Chromosomes humains de la paire 11
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Études de suivi
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Aberrations des chromosomes
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Génétique
/
Caryotypage
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Adult
/
Humans
/
Male
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2010
Type:
Article