Effect of kinetin on immunity and splenic lymphocyte proliferation in vitro in D-galactose-induced aging rats / 生理学报
Sheng Li Xue Bao
; (6): 605-611, 2014.
Article
de Zh
| WPRIM
| ID: wpr-255996
Bibliothèque responsable:
WPRO
ABSTRACT
The purpose of this paper is to study the effect of kinetin (Kn) on immunity and splenic lymphocyte proliferation in vitro of aging rats induced by D-galactose (D-gal). Fifty SD rats were randomly divided into five groups: control group, aging model group, Kn low dose group, Kn middle dose group and Kn high dose group. The aging model group was proposed by napes subcutaneous injection of D-gal (125 mg/kg) for 45 d, and anti-aging groups were intragastrically administered with 5, 10, 20 mg/kg of Kn respectively from day 11. IgG, IgA, IgM contents of serum, the apoptosis percentage, stimulation index (SI) and proliferation index (PI) of splenic lymphocyte in vitro were evaluated. The results showed that the apoptosis percentage of splenic lymphocyte in aging model rats was higher, the serum IgG, IgA and IgM contents, SI and PI were lower than control group. Kn significantly decreased the apoptosis percentage of splenic lymphocyte, while increased the serum IgG, IgA and IgM contents, SI and PI in aging model group. These results suggest that Kn could inhibit the apoptosis, while promote the proliferation of splenic lymphocyte, and then effectively enhance the immune power of the aging rats and slow down the aging process.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Rate
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Sang
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Vieillissement
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Lymphocytes
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Rat Sprague-Dawley
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Apoptose
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Biologie cellulaire
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Prolifération cellulaire
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Allergie et immunologie
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Sheng Li Xue Bao
Année:
2014
Type:
Article