A comparative study of EGFR and FGFR-2 expression in fetal and adult skin / 中华整形外科杂志
Chinese Journal of Plastic Surgery
; (6): 91-94, 2003.
Article
Dans Zh
| WPRIM
| ID: wpr-256473
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression characteristics of EGFR and FGFR-2 in normal skin from fetal and adult, and attempted to probe the molecule mechanism of fetal scarless healing.</p><p><b>METHODS</b>The skin samples of fetal and adult were taken from abortive fetus of obstetrics unit and donor site of plastic operation patients in our burn unit, respectively. EGFR and FGFR-2 were used as the biochemical markers for reparative cells. Immunohistochemistry staining technique was employed to determine the expressive levels of different epithelial cells markers.</p><p><b>RESULTS</b>There were EGFR and FGFR-2 antibody positive cells in normal skin from fetal and adult, but the expressive levels of EGFR and FGFR-2 protein had apparent difference, with the time of fetation increasing, the EGFR and FGFR-2 positive expression rate became stronger gradually. The number of FGFR-2 antibody positive cells found in adult skin was much more than that in fetal skin.</p><p><b>CONCLUSION</b>There were the inherent differences of EGFR and FGFR-2 antibody immunohistochemistry staining in cells of adult and fetal skin. which may be an essential facet of fetal scarless healing.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peau
/
Cicatrisation de plaie
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Immunohistochimie
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Récepteur ErbB-2
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Cellules épithéliales
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Foetus
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Récepteurs ErbB
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Métabolisme
Limites du sujet:
Adult
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Female
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Humans
langue:
Zh
Texte intégral:
Chinese Journal of Plastic Surgery
Année:
2003
Type:
Article