Chemical constituents from Morus notabilis and their cytotoxic effect / 药学学报
Acta Pharmaceutica Sinica
; (12): 579-582, 2015.
Article
de Zh
| WPRIM
| ID: wpr-257098
Bibliothèque responsable:
WPRO
ABSTRACT
Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Terpènes
/
Benzofuranes
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Flavonoïdes
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Extraits de plantes
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Chimie
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Concentration inhibitrice 50
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Morus
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Cellules HepG2
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Antinéoplasiques d'origine végétale
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2015
Type:
Article