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Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Article de En | WPRIM | ID: wpr-25785
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma. METHODS: We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis. RESULTS: The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p0.05). CONCLUSIONS: HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Acétylation / Pronostic / Immunohistochimie / Lymphocytes B / Histone / Technique de Western / Lymphome B / Lymphome T périphérique / Pseudolymphome / Histone acetyltransferases Type d'étude: Prognostic_studies langue: En Texte intégral: Korean Journal of Pathology Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Acétylation / Pronostic / Immunohistochimie / Lymphocytes B / Histone / Technique de Western / Lymphome B / Lymphome T périphérique / Pseudolymphome / Histone acetyltransferases Type d'étude: Prognostic_studies langue: En Texte intégral: Korean Journal of Pathology Année: 2012 Type: Article