Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Korean Journal of Pathology
; : 142-150, 2012.
Article
de En
| WPRIM
| ID: wpr-25785
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma. METHODS: We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis. RESULTS: The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p0.05). CONCLUSIONS: HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Acétylation
/
Pronostic
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Immunohistochimie
/
Lymphocytes B
/
Histone
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Technique de Western
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Lymphome B
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Lymphome T périphérique
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Pseudolymphome
/
Histone acetyltransferases
Type d'étude:
Prognostic_studies
langue:
En
Texte intégral:
Korean Journal of Pathology
Année:
2012
Type:
Article