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Cardioprotection against reperfusion injury: updated mechanisms and strategies / 生理学报
Sheng Li Xue Bao ; (6): 553-561, 2007.
Article de En | WPRIM | ID: wpr-258622
Bibliothèque responsable: WPRO
ABSTRACT
Early restoration of blood flow to the ischemic myocardium not only saves myocardium but also induces reperfusion injury. While no specific therapy to reduce reperfusion injury has yet been established, recent laboratory studies have shown that G protein-coupled receptor (GPCR) agonists, insulin, and postconditioning can effectively prevent reperfusion injury in various experimental settings and animal species. The potential mechanisms underlying the cardioprotection initiated by these interventions may include activation of the reperfusion injury salvage kinase (RISK) pathway, inactivation of glycogen synthase kinase 3beta (GSK-3beta), and modulation of mitochondrial permeability transition pore (mPTP) opening. These encouraging laboratory findings may help us develop successful clinical strategies to salvage reperfused myocardium in patients with acute myocardial infarction.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Physiologie / Lésion de reperfusion myocardique / Glycogen Synthase Kinase 3 / Protéines de transport de la membrane mitochondriale / Métabolisme / Infarctus du myocarde / Myocarde Limites du sujet: Humans langue: En Texte intégral: Sheng Li Xue Bao Année: 2007 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Physiologie / Lésion de reperfusion myocardique / Glycogen Synthase Kinase 3 / Protéines de transport de la membrane mitochondriale / Métabolisme / Infarctus du myocarde / Myocarde Limites du sujet: Humans langue: En Texte intégral: Sheng Li Xue Bao Année: 2007 Type: Article